BDBM615002 US20230271939, Comp Ex 2::WO2018030466, Example 123

SMILES COc1ncc(Cl)cc1S(=O)(=O)Nc1cccc(C#Cc2cnc(N)nc2)c1F

InChI Key InChIKey=KNLCRVWBKPPNBC-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 615002   

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615002(US20230271939, Comp Ex 2 | WO2018030466, Example 1...)
Affinity DataKi:  1.10nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615002(US20230271939, Comp Ex 2 | WO2018030466, Example 1...)
Affinity DataKi:  3.20nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615002(US20230271939, Comp Ex 2 | WO2018030466, Example 1...)
Affinity DataIC50: 10nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargeteIF-2-alpha kinase GCN2(Human)
Ip2Ipo Innovations

US Patent
LigandPNGBDBM615002(US20230271939, Comp Ex 2 | WO2018030466, Example 1...)
Affinity DataIC50: 70.7nMAssay Description:The inhibitory activity of the Example compounds towards GCN2 enzyme was measured according to the description below, using a LanthaScreen TR-FRET (T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent