BDBM616509 US20230278996, Example 17.

SMILES C[C@H]1CN([C@@H](Cc2ccc(Cl)cc2)CO1)C1CCN(CC1)c1ccccn1

InChI Key InChIKey=FMLSZVIGTSUDKD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 616509   

LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 78nMAssay Description:Displacement of biotinylated HSIII from human His-tagged CHI3L1 (1 to 383 residues) expressed in HEK293F cells by competitive AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 100nMAssay Description:The standard experimental protocol for YKL-40 indirect binding AlphaScreen assay comprised of 5 step additions to wells of a 96 well plate: (i) in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 118nMAssay Description:Displacement of biotinylated ((2R,5S)-5-(4-chlorobenzyl)-4-(1-(pyridin-2-yl)piperidin-4-yl)morpholin-2-yl)methyl 41-oxo-45-((3aS,4S,6aR)-2-oxohexahyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 130nMAssay Description:Displacement of biotinylated ((2R,5S)-5-(4-chlorobenzyl)-4-(1-(pyridin-2-yl)piperidin-4-yl)morpholin-2-yl)methyl 41-oxo-45-((3aS,4S,6aR)-2-oxohexahyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 323nMAssay Description:Inhibition of human C-terminal His tagged AMCase expressed in CHO-K1 cells using 4-methylumbelliferyl beta-D-N,N'-diacetylchitobioside hydrate as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 550nMAssay Description:The standard experimental protocol for YKL-40 indirect binding AlphaScreen assay comprised of 5 step additions to wells of a 96 well plate: (i) in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
US Patent

TargetChitinase-3-like protein 2(Homo sapiens)TBA
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of biotinylated ((2R,5S)-5-(4-chlorobenzyl)-4-(1-(pyridin-2-yl)piperidin-4-yl)morpholin-2-yl)methyl 41-oxo-45-((3aS,4S,6aR)-2-oxohexahyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetChitotriosidase-1(Human)TBA
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human C-terminal His tagged CHIT1 expressed in CHO-K1 cells using 4-methylumbelliferyl beta-D-N,N',N''-triacetylchitotrioside as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetChitinase-3-like protein 1(Mus musculus)TBA
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataKd:  3.00E+3nMAssay Description:Binding affinity to mouse His-tagged CHI3L1 assessed as dissociation constant incubated for 10 mins by NT647 fluorescent dye based microscale thermop...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetChitinase-3-like protein 1(Mus musculus)TBA
LigandPNGBDBM616509(US20230278996, Example 17.)
Affinity DataIC50: 7.40E+3nMAssay Description:Displacement of biotinylated ((2R,5S)-5-(4-chlorobenzyl)-4-(1-(thiazol-2-yl)piperidin-4-yl)morpholin-2-yl)methyl 41-oxo-45-((3aS,4S,6aR)-2-oxohexahyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed