BDBM6192 US8802686, 3::US8802686, C3

SMILES C[C@@H](Oc1nc(Nc2ccc(cc2)S(C)(=O)=O)ncc1C(F)(F)F)C(C)(C)O

InChI Key InChIKey=PAEDTQQTYBULPN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 6192   

TargetCyclin-dependent kinase 2(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 9nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 2(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:CDK2/CycE (50 mg/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 uM, and within ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 24nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 1(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:CDK1/CycB (200 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substances (0 and within the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 78nMpH: 7.0 T: 2°CAssay Description:Recombinant CDK4 and CycD1-GST fusion proteins, purified from baculovirus-infected insect cells (Sf9), were purchased from ProQinase GmbH, Freiburg. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 190nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Intellectual Property

US Patent
LigandPNGBDBM6192(US8802686, 3 | US8802686, C3)
Affinity DataIC50: 490nMpH: 5.5 T: 2°CAssay Description:VEGF receptor tyrosine kinase (90 ng/measuring point) was incubated for 10 min at 22 C. in the presence of different concentrations of test substance...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent