BDBM620017 Methyl (4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizin-3-yl)-1H-imidazol-5-yl)phenyl)carbamate::US20230295157, Example 341

SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)[C@@H]1CC[C@@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620017   

TargetKallikrein-1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620017(Methyl (4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-...)
Affinity DataIC50:  1.30nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620017(Methyl (4-(2-((3S,8aR)-7-(3-chloro-2-fluoro-6-(1H-...)
Affinity DataIC50:  0.200nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent