BDBM620047 (3S,8aR)-3-(5-(2-aminopyridin-4-yl)-4-chloro-1H-imidazol-2-yl)-7-(3-chloro-2-fluoro-6-(1H-tetrazol-1-yl)phenyl)-2,3,8,8a-tetrahydroindolizin-5(1H)-one::US20230295157, Example 372

SMILES Nc1cc(ccn1)-c1[nH]c(nc1Cl)[C@@H]1CC[C@@H]2CC(=CC(=O)N12)c1c(F)c(Cl)ccc1-n1cnnn1

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 620047   

TargetKallikrein-1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620047((3S,8aR)-3-(5-(2-aminopyridin-4-yl)-4-chloro-1H-im...)
Affinity DataIC50:  1.20nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of human plasma kallikrein. The peptide substrate, Z-Gly-Pro-Arg-AMC (Pur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM620047((3S,8aR)-3-(5-(2-aminopyridin-4-yl)-4-chloro-1H-im...)
Affinity DataIC50:  0.300nMAssay Description:A fluorescence intensity (FLINT) based assay was used to monitor inhibition of Factor XIa. The peptide substrate, 5Fam-KLTRAETV-K5Tamra (purchased fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent