BDBM621088 2-(3-(3,5-difluoro-6- (((3S,4S)-4-fluoro- piperidin-3-yl)- amino)pyridin-2-yl)- imidazo[1,2-a]- pyridin-6-yl)propan- 2-ol::US20230303563, Compound 28

SMILES CC(C)(O)c1ccc2ncc(-c3nc(N[C@H]4CNCC[C@@H]4F)c(F)cc3F)n2c1

InChI Key InChIKey=MMKIEBBLOVSLAS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 621088   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621088BDBM621088(2-(3-(3,5-difluoro-6- (((3S,4S)-4-fluoro- piperidi...)
Affinity DataIC50: 0.800nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621088BDBM621088(2-(3-(3,5-difluoro-6- (((3S,4S)-4-fluoro- piperidi...)
Affinity DataIC50: 1nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621088BDBM621088(2-(3-(3,5-difluoro-6- (((3S,4S)-4-fluoro- piperidi...)
Affinity DataIC50: 28nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent