BDBM621097 N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6- (trifluoromethoxy)- imidazo[1,2-a]pyridin- 3-yl)pyridin-2-amine::US20230303563, Compound 48

SMILES F[C@H]1CNC[C@@H]1Nc1cccc(n1)-c1cnc2ccc(OC(F)(F)F)cn12

InChI Key InChIKey=XMWONVHOMANOOY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 621097   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621097BDBM621097(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6- (trifl...)
Affinity DataIC50: 0.800nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621097BDBM621097(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6- (trifl...)
Affinity DataIC50: 1nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621097BDBM621097(N-((3S,4S)-4-fluoro- pyrrolidin-3-yl)-6-(6- (trifl...)
Affinity DataIC50: 100nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent