BDBM621104 6-(6-(1-(difluorometh- yl)-1 H-pyrazol-4-yl)-7- methoxyimidazo[1,2-a]- pyridin-3-yl)-N-((3R,4S)- 4-(trifluoromethyl)- pyrrolidin-3-yl)pyridin- 2-amine::US20230303563, Compound 62

SMILES COc1cc2ncc(-c3cccc(N[C@H]4CNC[C@@H]4C(F)(F)F)n3)n2cc1-c1cnn(c1)C(F)F

InChI Key InChIKey=UZBFFCBUJQNOPY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 621104   

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621104BDBM621104(6-(6-(1-(difluorometh- yl)-1 H-pyrazol-4-yl)-7- me...)
Affinity DataIC50: 0.800nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621104BDBM621104(6-(6-(1-(difluorometh- yl)-1 H-pyrazol-4-yl)-7- me...)
Affinity DataIC50: 1nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 1(Human)
Children'S Hospital Medical Center

US Patent
LigandChemical structure of BindingDB Monomer ID 621104BDBM621104(6-(6-(1-(difluorometh- yl)-1 H-pyrazol-4-yl)-7- me...)
Affinity DataIC50: 130nMAssay Description:Table 32: The reagent used was as follows: Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.016 Brij35, 0.02 mg/ml BSA, 0.1 mM N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
US Patent