BDBM6221 8-Ethyl-2-phenylamino-8H-pyrido[2,3-d]pyrimidin-7-one::8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::C2 Pyrido[2,3-d]pyrimidin-7-one deriv. 1

SMILES CCn1c2nc(Nc3ccccc3)ncc2ccc1=O

InChI Key InChIKey=WSZLNFZLFQJSAJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 6221   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 129nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 410nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 620nMAssay Description:Inhibition of CDK4 (unknown origin) using GST-fused pRb (792 to 928) as substrate preincubated for 2 mins followed by [gamma-32P]-ATP addition measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 620nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 1.02E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6221(8-ethyl-2-(phenylamino)-7H,8H-pyrido[2,3-d]pyrimid...)
Affinity DataIC50: 3.30E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed