BDBM622422 US20230312576, Compound 78

SMILES COc1ccc(cc1)-c1cccc(NC(=O)N2CCC(=CC2)c2ncnc3[nH]cc(C4CC4)c23)c1

InChI Key InChIKey=VMMJPRHBWAWSAE-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 622422   

TargetLIM domain kinase 1(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM622422(US20230312576, Compound 78)
Affinity DataKi:  19.8nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent

TargetLIM domain kinase 1(Human)
Centre National De La Recherche Scientifique

US Patent
LigandPNGBDBM622422(US20230312576, Compound 78)
Affinity DataKi:  20nMAssay Description:Inhibition of LIMK1 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM622422(US20230312576, Compound 78)
Affinity DataKi:  21nMAssay Description:Inhibition of LIMK2 (unknown origin) assessed as inhibition constant by LanthScreen Eu kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
University of Orleans

Curated by ChEMBL
LigandPNGBDBM622422(US20230312576, Compound 78)
Affinity DataKi:  21.1nMAssay Description:Inhibition of LIMK1 and LIMK2. Inhibition of LIMK1 and LIMK2 was measured with Lanthascreen Eu binding assay (Life Technologies). This TR-FRET assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2023
Entry Details
US Patent