BDBM625005 US20230322747, Compound 29

SMILES FC(F)c1nnc(o1)-c1ccc(COc2cccc(F)c2C#N)nc1

InChI Key InChIKey=LNTXQVBPYCHJLK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 625005   

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM625005(US20230322747, Compound 29 | US20250250263, Compou...)
Affinity DataIC50: 50nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, if app...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 6(Human)TBA
LigandPNGBDBM625005(US20230322747, Compound 29 | US20250250263, Compou...)
Affinity DataIC50: 50nMAssay Description:The biochemical HDAC6 assay was performed using fluorescence detection (Fluor-De-Lys assay). In this assay, deacetylation of the Lysine residue in th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent

TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM625005(US20230322747, Compound 29 | US20250250263, Compou...)
Affinity DataIC50: 5.50E+4nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, if app...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetHistone deacetylase 8(Human)TBA
LigandPNGBDBM625005(US20230322747, Compound 29 | US20250250263, Compou...)
Affinity DataIC50: 5.50E+4nMAssay Description:HDAC reactions were assembled in 384 well plates (Greiner) in a total volume of 20 μL as follows: HDAC proteins (and their regulatory subunit, i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
US Patent