BDBM626354 2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluoromethoxy)phenyl]-3H- benzofuran-5-yl]amino]methyl]prop- 2-enehydroxamic acid::US11787775, Compound 37::US11787775, Compound 39

SMILES ONC(=O)C(=C)CNc1cc(c2OCCc2c1C#N)-c1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=APBLUHIZDWYDCV-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 626354   

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-4(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 40nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-1(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-3(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 60nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 60nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 140nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 180nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 400nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

TargetTranscriptional enhancer factor TEF-5(Human)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 420nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 700nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent

LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50: 710nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2023
Entry Details
Go to US Patent