BDBM628626 (3R)-3-[(1-acetylazetidin-3-yl)methoxy]-3-(4-chlorophenyl)-2-[(5-chloropyridin-2-yl)methyl]-6-(2- hydroxypropan-2-yl)-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 64

SMILES CC(=O)N1CC(CO[C@]2(N(Cc3ccc(Cl)cn3)C(=O)c3cc(ccc23)C(C)(C)O)c2ccc(Cl)cc2)C1

InChI Key InChIKey=MTCWJKWIYJJMBM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 628626   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628626BDBM628626((3R)-3-[(1-acetylazetidin-3-yl)methoxy]-3-(4-chlor...)
Affinity DataIC50: 40nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent