BDBM628629 (3R)-3-(4-Chlorophenyl)-2-[(5-chloropyridin-2-yl)methyl]-6-(1,2-dihydroxypropan-2-yl)-4-fluoro-3- ({1-[hydroxy(2H2)methyl]cyclopropyl}(2H2)methoxy)-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 16::US20230338337, Compound 17

SMILES CC1CC1(O)[C@@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(cc(F)c12)C(C)(O)CO)c1ccc(Cl)cc1

InChI Key InChIKey=AVONVAVGLVSHHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 628629   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628629BDBM628629(US20230338337, Compound 16 | (3R)-3-(4-Chloropheny...)
Affinity DataIC50: 3.80nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628629BDBM628629(US20230338337, Compound 16 | (3R)-3-(4-Chloropheny...)
Affinity DataIC50: 30nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent