BDBM628737 (3R)-3-(4-Chlorophenyl)-2-[(5-chloropyridin-2-yl)methyl]-4-fluoro-6-(2-hydroxypropan-2-yl)-3-[(1- methanesulfinylcyclopropyl)methoxy]-2,3-dihydro-1H-isoindol-1-one::US20230338337, Compound 171::US20230338337, Compound 172

SMILES CS(=O)C1(CO[C@]2(N(Cc3ccc(Cl)cn3)C(=O)c3cc(cc(F)c23)C(C)(C)O)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=BMDCWINLUAOPGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 628737   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628737BDBM628737(US20230338337, Compound 172 | US20230338337, Compo...)
Affinity DataIC50: 130nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Otsuka Pharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 628737BDBM628737(US20230338337, Compound 172 | US20230338337, Compo...)
Affinity DataIC50: 140nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent