BDBM629335 US20230339981, Example 17

SMILES Oc1cc(-c2nc3OC[C@@H]4[C@@H]5CC[C@H](CN4c4nc(OC[C@@]67CCCN6C[C@H](F)C7)nc(c2F)c34)N5)c2c(Cl)cccc2c1

InChI Key InChIKey=JAFOQUTZMCAMCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 629335   

TargetGTPase KRas [G12D](Human)
Gilead Sciences

US Patent
LigandPNGBDBM629335(US20230339981, Example 17)
Affinity DataIC50: 0.400nMAssay Description:Compounds were tested for binding to GDP-loaded KRAS G12D in a 384-well assay format using a TR-FRET probe displacement assay in buffer consisting of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM629335(US20230339981, Example 17)
Affinity DataIC50: 5nMAssay Description:Inhibition of ERK1/2 phosphorylation in human PANC-1 cells incubated for 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed