BDBM631515 N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethyl)-4- (((1R,5S,6s)-3-methyl-3- azabicyclo[3.1.0]hexan-6- yl)amino)-1-(3- methylbicyclo[1.1.1]penta n-1-yl)-6-oxo-1,6- dihydropyridine-3- carboxamide::US20230348424, Example 98

SMILES C[C@@H](NC(=O)c1cn(c(=O)cc1N[C@@H]1[C@H]2CN(C)C[C@@H]12)C12CC(C)(C1)C2)c1cccc(C(F)F)c1F

InChI Key InChIKey=IXYGGZPQRHHYIE-XBESVKIMSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 631515   

TargetSon of sevenless homolog 1 [564-1049]()
SchröDinger

US Patent
LigandPNGBDBM631515(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)
Affinity DataKd:  6nMAssay Description:Binding to SOS1 was measured using a SPR assay with purified recombinant human SOS1 substrate (res. 564-1049 with N-terminal Avi tag; purified and bi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSon of sevenless homolog 1 [564-1049]/GTPase KRas [G12C](Homo sapiens (Human))
SchröDinger

US Patent
LigandPNGBDBM631515(N-((R)-1-(3- (difluoromethyl)-2- fluorophenyl)ethy...)
Affinity DataIC50:  13.4nMAssay Description:Inhibition of the SOS 1:KRAS interaction was measured using purified GST-tagged KRAS (res. 1-169, G12C, purified based on Hillig, et al., Proc Natl A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent