BDBM6351 2-Aminoquinazoline 30::8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)phenyl]amino}quinazolin-7-ol

SMILES Cc1cc(O)c(C2CCCC2)c2nc(Nc3ccc(cc3)N3CCNCC3)ncc12

InChI Key InChIKey=LNKPBQMYLJEWNJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 6351   

LigandPNGBDBM6351(8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)pheny...)
Affinity DataIC50: 20nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Naeja Pharmaceutical

LigandPNGBDBM6351(8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)pheny...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
LigandPNGBDBM6351(8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)pheny...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Naeja Pharmaceutical

LigandPNGBDBM6351(8-cyclopentyl-5-methyl-2-{[4-(piperazin-1-yl)pheny...)
Affinity DataIC50: 5.00E+3nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2005
Entry Details Article
PubMed