BDBM635974 (1R,2S)-5'-methoxy-2-(3-{[3-methoxy-6-(morpholin-4-yl)pyrazin-2-yl]amino}-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 99

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(Nc4nc(N5CCOCC5)cnc4OC)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=XVTGWJWSWNCTFK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 635974   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635974BDBM635974(US20230365537, Example 99 | (1R,2S)-5'-methoxy-2-(...)
Affinity DataIC50: 5.80nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635974BDBM635974(US20230365537, Example 99 | (1R,2S)-5'-methoxy-2-(...)
Affinity DataIC50: 754nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 635974BDBM635974(US20230365537, Example 99 | (1R,2S)-5'-methoxy-2-(...)
Affinity DataIC50: 900nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent