BDBM636015 (1R,2R)-2-(3-{[5-(difluoromethoxy)-2-methylpyrimidin-4-yl]amino}-7-fluoro-1H-indazol-6-yl)-5'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one::US20230365537, Example 143

SMILES Cc1ncc(OC(F)F)c(Nc2n[nH]c3c(F)c([C@@H]4C[C@@]45C(=O)Nc4ccc(F)cc45)ccc23)n1

InChI Key InChIKey=OSZYQQFLZMXEML-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636015   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636015BDBM636015(US20230365537, Example 143 | (1R,2R)-2-(3-{[5-(dif...)
Affinity DataIC50: 84.7nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636015BDBM636015(US20230365537, Example 143 | (1R,2R)-2-(3-{[5-(dif...)
Affinity DataIC50: 1.24E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636015BDBM636015(US20230365537, Example 143 | (1R,2R)-2-(3-{[5-(dif...)
Affinity DataIC50: 3.44E+3nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent