BDBM636082 (1R,2S)-2-{3-[(2,5-dimethyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl)amino]-1H-indazol-6-yl}-5'-methoxyspiro[cyclopropane-1,3'-indol]-2'(1'H)-one (single diastereomer of unknown absolute configuration)::US20230365537, Example 211

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(Nc4nc(C)nc5c4C(C)SC5)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=UBSYFUQJIKSDBY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 636082   

TargetSerine/threonine-protein kinase PLK4(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636082BDBM636082(US20230365537, Example 211 | (1R,2S)-2-{3-[(2,5-di...)
Affinity DataIC50: 8.66nMAssay Description:Activity of human recombinant PLK4 (ThermoFisher, cat #PV6396) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo Kinase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase B(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636082BDBM636082(US20230365537, Example 211 | (1R,2S)-2-{3-[(2,5-di...)
Affinity DataIC50: 1.89E+3nMAssay Description:Activity of human recombinant Aurora B (ThermoFisher, cat #PR9210B) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent

TargetAurora kinase A(Human)
Oric Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 636082BDBM636082(US20230365537, Example 211 | (1R,2S)-2-{3-[(2,5-di...)
Affinity DataIC50: 4.61E+3nMAssay Description:Activity of human recombinant Aurora A (ThermoFisher, cat #PR5935A) was measured by quantification of adenosine diphosphate (ADP) using the ADP-Glo K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2024
Entry Details
US Patent