BDBM636331 US20230365546, Compound 114

SMILES CCCCn1cc(C(=O)N[C@@H](C)c2cccc(F)c2)c2cc(ccc12)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1

InChI Key InChIKey=METYSAZOGNFXRX-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636331   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Origiant Pharmaceutical

US Patent

LigandBDBM636331(US20230365546, Compound 114)Copy SMILESCopy InChI

Affinity DataIC50: 55nMAssay Description:In vitro kinase assays were conducted using Kinase Profiler services provided by Eurofins. The experimental method was as follows: the small molecule...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
1/12/2024
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Origiant Pharmaceutical

US Patent

LigandBDBM636331(US20230365546, Compound 114)Copy SMILESCopy InChI

Affinity DataIC50: 76nMAssay Description:Inhibition of human RIPK1 (1 to 294 residues) preincubated for 15 mins followed by [gamma-33P]ATP addition and measured after 40 mins by scintillatio...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
TBA
Entry Details
Copy BDB DOIPubMed
Copy reaction URL