BDBM636356 US20230365546, Compound 139

SMILES CC(C)C(=O)Nc1nc2cc(ccn2n1)-c1ccc2n(C)cc(C(=O)NC(C)c3ccncc3)c2c1

InChI Key InChIKey=GZHDJXNATQNZSZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 636356   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM636356(US20230365546, Compound 139)
Affinity DataIC50: 26nMAssay Description:Inhibition of human RIPK1 (1 to 294 residues) preincubated for 15 mins followed by [gamma-33P]ATP addition and measured after 40 mins by scintillatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM636356(US20230365546, Compound 139)
Affinity DataIC50: 55nMAssay Description:In vitro kinase assays were conducted using Kinase Profiler services provided by Eurofins. The experimental method was as follows: the small molecule...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/12/2024
Entry Details
US Patent