BDBM636473 N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)acetamide (Racemate)::US20230365554, Example 42::US20230365554, Example 43::US20230365554, Example 44

SMILES CN1CC(CC(F)F)c2[nH]c(c(Nc3ccccc3)c2C1=O)-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1

InChI Key

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 636473   

TargetCasein kinase I isoform alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  1.80nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  4.10nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  2.80nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  4.30nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  490nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform delta(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  5.90nMAssay Description:CSNK1D-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  1.10E+3nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  410nMAssay Description:Recombinant fusion protein of N-terminal Glutathion-S-Transferase (GST) and a fragment of human EGFR (amino acids R669 to A1210), expressed in Sf9 in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
The Broad Institute

US Patent
LigandPNGBDBM636473(N-{4-[3-anilino-7-(2,2-difluoroethyl)-5-methyl-4-o...)
Affinity DataIC50:  3.30nMAssay Description:CSNK1A1-inhibitory activity of compounds of the present invention in presence of 1 μM adenosine-tri-phosphate (ATP) was quantified employing the...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent