BDBM637687 US11834440, Compound RF-1B

SMILES O=C1C[C@H](c2c(F)cc(OCCC(F)F)cc2F)N1c1ccc2[nH]cnc2c1

InChI Key InChIKey=GURVAWDLVHIGNH-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 637687   

TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to QPTCL (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataKi:  2.40nMAssay Description:Binding affinity to QPCT (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetGlutaminyl-peptide cyclotransferase-like protein(Human)
Tongji University Cancer Center

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 637687BDBM637687(US11834440, Compound RF-1B)
Affinity DataIC50: 13.5nMAssay Description:Preparation of working solution: 2×Glutaminyl Cyclase substrate was diluted in assay buffer to 5 M. 2×enzyme solution and QPCTL was diluted in assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2024
Entry Details
US Patent