BDBM640487 US20230399319, Example 2-032

SMILES CC(=O)N1CCCN(CC1)S(=O)(=O)NC(=O)c1coc(Nc2cc(ccc2C)C(F)(F)F)n1

InChI Key InChIKey=DGJLHUJPHIKPOH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 640487   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM640487(US20230399319, Example 2-032)
Affinity DataIC50: 66nMAssay Description:Inhibition of NLRP3 in LPS/nigericin-induced human THP-1 cells assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM640487(US20230399319, Example 2-032)
Affinity DataIC50: 89nMAssay Description:The NLRP3 inflammasome inhibitory activity of test compounds were evaluated CM the basis of the inhibitory activity of the IL-1β, production in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/3/2024
Entry Details
US Patent

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM640487(US20230399319, Example 2-032)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of NLRP3 in human whole blood assessed as inhibition of IL-1beta production pretreated with LPS for 3 hrs followed by incubation with comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed