BDBM642329 US20230405002, Example 10::US20230405002, Example 9::rac-2-{5-[(3-ethoxypyridin-2-yl)oxy]pyridin- 3-yl}-N-[(3R,6S)-6- (trifluoromethyl)piperidin-3-yl]pyrimidine-5- carboxamide

SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@@H]1CC[C@H](NC1)C(F)(F)F

InChI Key InChIKey=PYMOGDZRMJREBT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 642329   

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642329(US20230405002, Example 10 | rac-2-{5-[(3-ethoxypyr...)
Affinity DataIC50: 19nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent

TargetDiacylglycerol O-acyltransferase 2(Human)
Pfizer

US Patent
LigandPNGBDBM642329(US20230405002, Example 10 | rac-2-{5-[(3-ethoxypyr...)
Affinity DataIC50: 39nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2024
Entry Details
US Patent