BDBM644426 5-((2-(4-((3- cyano-4- cyclobutoxy- benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 20

SMILES NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1ccc(OC3CCC3)c(c1)C#N)c1ccncc21

InChI Key InChIKey=PWHUGOZQQCNCHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644426   

TargetCasein kinase II subunit alpha [2-329](Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644426(US11866436, Example 20 | 5-((2-(4-((3- cyano-4- cy...)
Affinity DataIC50: 0.278nMAssay Description:Final assay conditions comprised 0.2 nM CK2α, 50 μM peptide substrate (RRRADDSDDDDD), 15 μM ATP in 1× reaction buffer (40 mM Tris pH7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent

TargetDual specificity protein kinase CLK2(Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644426(US11866436, Example 20 | 5-((2-(4-((3- cyano-4- cy...)
Affinity DataIC50: 609nMAssay Description:The assay was conducted in the same way as described for CK2α, with final assay conditions comprising 20 nM CLK2 (Carna Biosciences-04-127), 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
US Patent