BDBM647801 US20240025919, Compound 28

SMILES CCc1cccc2cc(O)cc(-c3nc4c5c(nc(OCC67COC(C6)C7)nc5c3F)N3C[C@H]5CC[C@H](N5)[C@H]3[C@H](C)O4)c12

InChI Key InChIKey=KPNZIRXECJLVHK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647801   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 647801BDBM647801(US20240025919, Compound 28)
Affinity DataIC50: 9.38nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 647801BDBM647801(US20240025919, Compound 28)
Affinity DataIC50: 751nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent