BDBM647807 US20240025919, Compound 34

SMILES Cc1cc(N)c(F)c(-c2nc3c4c(nc(OC[C@@]56CCCN5C[C@H](F)C6)nc4c2F)N2C[C@H]4CC[C@H](N4)[C@H]2[C@H](C)O3)c1C(F)(F)F

InChI Key InChIKey=IRTZMVDITNIDFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647807   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 647807BDBM647807(US20240025919, Compound 34)
Affinity DataIC50: 0.235nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent

TargetGTPase KRas(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 647807BDBM647807(US20240025919, Compound 34)
Affinity DataIC50: 2.13nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent