BDBM648145 US20240025922, Example 113

SMILES COC1CCN(CC1)c1ccc(Nc2ncc3CCN(Cc3n2)c2cnc3OCCNc3c2C)cc1

InChI Key InChIKey=YMEFODZSORZQKP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 648145   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM648145(US20240025922, Example 113)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged HPK1 expressed in baculovirus infected Sf21 insect cells preincubated for 15 mins f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM648145(US20240025922, Example 113)
Affinity DataIC50: 100nMAssay Description:A recombinant fusion protein consisting of full-length human HPK1 (MAP4K1) with an N-terminal Glutatione S-transferase (GST) tag was produced in inse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
US Patent