BDBM648367 acsmedchemlett.2c00502 OICR 8312A, 20

SMILES Nc1ncnc2n(CC(=O)Nc3ccncc3Cl)ccc12

InChI Key InChIKey=VAOFXUUJLLQNIX-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 648367   

TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandChemical structure of BindingDB Monomer ID 648367BDBM648367(acsmedchemlett.2c00502 OICR 8312A, 20)
Affinity DataKd:  4.37E+5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer. Data...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandChemical structure of BindingDB Monomer ID 648367BDBM648367(acsmedchemlett.2c00502 OICR 8312A, 20)
Affinity DataKd:  4.37E+5nMAssay Description:We used a more sensitive Surface Plasmon Resonance (SPR) assay to quantitate the direct binding affinity of ligands to purified BCL6-BTB dimer.More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed
TargetB-cell lymphoma 6 protein [5-128](Human)
Ontario Institute for Cancer Research

LigandChemical structure of BindingDB Monomer ID 648367BDBM648367(acsmedchemlett.2c00502 OICR 8312A, 20)
Affinity DataIC50: 5.00E+5nMAssay Description:To identify small molecule BCL6 inhibitors, we developed a Fluorescence Polarization (FP) assay to assess the ability of ligands to compete with a fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2024
Entry Details
PubMed