BDBM648808 N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- azaspiro[4.5]decan-2-yl)pyrido[3,4-d]pyrimidin-2- amine::US20240034731, Compound 7::US20250235456, Compound 7

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccnc(N3CCC4(C3)CCOCC4)c2n1

InChI Key InChIKey=ZESHYLXLVLHWMK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 648808   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin El assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 350nMAssay Description:The purpose of CDK1/Cyclin Bi assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648808(N-(1-(methylsulfonyl)piperidin-4-yl)-8-(8-oxa-2- a...)
Affinity DataIC50: 375nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent