BDBM648817 (3aR,8bR)-2-(2-((1-(methylsulfonyl)piperidin-4- yl)amino)pyrido[3,4-d]pyrimidin-8-yl)-2,3,3a,8b- tetrahydro-1H-benzo[4,5]thieno[2,3-c]pyrrole 4,4- dioxide::US20240034731, Compound 16

SMILES CS(=O)(=O)N1CCC(CC1)Nc1ncc2ccnc(C3C[C@@H]4[C@H](C3)S(=O)(=O)c3ccccc43)c2n1

InChI Key InChIKey=DNEVEYWCBMHOSI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 648817   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648817((3aR,8bR)-2-(2-((1-(methylsulfonyl)piperidin-4- yl...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648817((3aR,8bR)-2-(2-((1-(methylsulfonyl)piperidin-4- yl...)
Affinity DataIC50: 200nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by using a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648817((3aR,8bR)-2-(2-((1-(methylsulfonyl)piperidin-4- yl...)
Affinity DataIC50: 200nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648817((3aR,8bR)-2-(2-((1-(methylsulfonyl)piperidin-4- yl...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent