BDBM648855 N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methyl-8-(6-methyl-2,6-diazaspiro[3.4]octan-2- yl)pyrido[3,4-d]pyrimidin-2-amine::US20240034731, Compound 49

SMILES CN1CCC2(CN(C2)c2nc(C)cc3cnc(NC4CCN(CC4)S(=O)(=O)C4CC4)nc23)C1

InChI Key InChIKey=NUEFFTPUFYWSFG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 648855   

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin E1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Chelation-En...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 200nMAssay Description:The purpose of CDK2/Cyclin El assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 350nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 375nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition and IC50 values) in the presence of small molecule inhibitors by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Spiny starfish)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 1.25E+3nMAssay Description:The purpose of CDK1/Cyclin Bi assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2025
Entry Details
US Patent

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Iambic Therapeutics

US Patent
LigandPNGBDBM648855(N-(1-(cyclopropylsulfonyl)piperidin-4-yl)-6- methy...)
Affinity DataIC50: 1.25E+3nMAssay Description:The purpose of CDK1/Cyclin B1 assay is to evaluate the inhibition (% inhibition and IC50 values) of small molecule inhibitors by using a Luminescent ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
US Patent