BDBM651046 US20240043448, Example 110

SMILES CC(C)c1nccc2OCCOc3c(F)ccc(F)c3-c3nc4n(-c12)c(=O)nc(N1CC(C)N(CC1C)C(=O)C=C)c4cc3C

InChI Key InChIKey=KRHDSGYGDCCGTG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 651046   

TargetGTPase KRas [2-169,G12C,C51S,C80L,C118S](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM651046(US20240043448, Example 110)
Affinity DataIC50: 4.5nMAssay Description:Each test compound (10 mM stock in DMSO) is diluted in DMSO to make a 10-point, 3-fold dilution series in a 384-well low dead volume microplate (Labc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
US Patent