BDBM652124 US11905258, Example 68-39450

SMILES CN(C)CC12CC(n3cc(Nc4ncc5cc(Cl)c(C6CCN(C7(C)COC7)CC6)cc5n4)cn3)(C1)C2

InChI Key InChIKey=RVBPLJZOSGHYNI-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652124   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 652124BDBM652124(6-chloro-N-(1-{3- [(dimethylamino)methyl]bicyclo [...)
Affinity DataIC50: 0.631nMAssay Description:The ability of compounds to modulate production of amyloid beta protein Abeta(1-42) was determined using human WT-APP overexpressing CHO cells. Cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2026
Entry Details US Patent