BDBM652441 7-N-({6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-yl}methyl)quinazoline-4,7-diamine::US20240059691, Example 1021

SMILES CN1CCC(COc2ccc(CNc3ccc4c(N)ncnc4c3)cn2)CC1

InChI Key InChIKey=MWKRRXJZGCNJCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652441   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652441BDBM652441(US20240059691, Example 1021 | 7-N-({6-[(1-methylpi...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent