BDBM652447 6-N-({2-methoxy-6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-yl}methyl)isoquinoline- 1,6-diamine::US20240059691, Example 1027

SMILES COc1nc(OCC2CCN(C)CC2)ccc1CNc1ccc2c(N)nccc2c1

InChI Key InChIKey=DUIWPUICWUPZLF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652447   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652447BDBM652447(US20240059691, Example 1027 | 6-N-({2-methoxy-6-[(...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent