BDBM652458 4-chloro-6-N-[(2-{[3-(1-methylimidazol-2-yl)propyl]amino}pyrimidin-5- yl)methyl]isoquinoline-1,6-diamine::US20240059691, Example 1038

SMILES Cn1ccnc1CCCNc1ncc(CNc2ccc3c(N)ncc(Cl)c3c2)cn1

InChI Key InChIKey=FYYSNZXHRLKRRU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652458   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652458BDBM652458(US20240059691, Example 1038 | 4-chloro-6-N-[(2-{[3...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent