BDBM652481 N5-((6-(8-methyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)pyridin-3- yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 1150

SMILES CC1N(CCn2ccnc12)c1ccc(CNc2cccc3c(N)nccc23)cn1

InChI Key InChIKey=YSHBWHHQCNCYQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652481   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652481BDBM652481(US20240059691, Example 1150 | N5-((6-(8-methyl-5,6...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652481BDBM652481(US20240059691, Example 1150 | N5-((6-(8-methyl-5,6...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent