BDBM652483 2-(7-(5-(((1-aminoisoquinolin-5-yl)amino)methyl)pyridin-2-yl)-5,6,7,8- tetrahydroimidazo[1,2-a]pyrazin-2-yl)propan-2-ol::US20240059691, Example 1163

SMILES CC(C)(O)c1cn2CCN(Cc2n1)c1ccc(CNc2cccc3c(N)nccc23)cn1

InChI Key InChIKey=CFABJMBLMVPGCU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652483   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652483BDBM652483(US20240059691, Example 1163 | 2-(7-(5-(((1-aminois...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652483BDBM652483(US20240059691, Example 1163 | 2-(7-(5-(((1-aminois...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent