BDBM652486 2-[(3S)-1-(5-{[(1-amino-4-chloroisoquinolin-6-yl)amino]methyl}pyridin-2-yl)pyrrolidin-3- yl]propan-2-ol::US20240059691, Example 1176

SMILES CC(C)(O)[C@H]1CCN(C1)c1ccc(CNc2ccc3c(N)ncc(Cl)c3c2)cn1

InChI Key InChIKey=MXLBORNZGRKMKV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652486   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652486BDBM652486(US20240059691, Example 1176 | 2-[(3S)-1-(5-{[(1-am...)
Affinity DataIC50: 6.50E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652486BDBM652486(US20240059691, Example 1176 | 2-[(3S)-1-(5-{[(1-am...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent