BDBM652487 N5-((6-((2-(1-(difluoromethyl)-1H-imidazol-2-yl)ethyl)amino)pyridin-3- yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 1181

SMILES Nc1nccc2c(NCc3ccc(NCCc4nccn4C(F)F)nc3)cccc12

InChI Key InChIKey=LZTSERAEHCDHEM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652487   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652487BDBM652487(US20240059691, Example 1181 | N5-((6-((2-(1-(diflu...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652487BDBM652487(US20240059691, Example 1181 | N5-((6-((2-(1-(diflu...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent