BDBM652521 2-methyl-N-((6-((1-methylpiperidin-4-yl)methoxy)pyridin-3-yl)methyl)-1H-pyrrolo[2,3- b]pyridin-4-amine::US20240059691, Example 1249

SMILES Cc1cc2c(NCc3ccc(OCC4CCN(C)CC4)nc3)ccnc2[nH]1

InChI Key InChIKey=CSOIEWKCRIAOFP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652521   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652521BDBM652521(US20240059691, Example 1249 | 2-methyl-N-((6-((1-m...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652521BDBM652521(US20240059691, Example 1249 | 2-methyl-N-((6-((1-m...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent