BDBM652587 (5-(((1-aminoisoquinolin-5-yl)amino)methyl)-2-(3-(trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-3-yl)methanol::US20240059691, Example 1335

SMILES Nc1nccc2c(NCc3cnc(N4CCn5c(C4)nnc5C(F)(F)F)c(CO)c3)cccc12

InChI Key InChIKey=QMKBLLYFSWTJBU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652587   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652587BDBM652587(US20240059691, Example 1335 | (5-(((1-aminoisoquin...)
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent