BDBM652625 6-N-({2-fluoro-4-[({5-methyl-2-oxa-5-azaspiro[3.5]nonan-8- yl}oxy)methyl]phenyl}methyl)isoquinoline-1,6-diamine::US20240059691, Example 2205

SMILES CN1CCC(CC11COC1)OCc1ccc(CNc2ccc3c(N)nccc3c2)c(F)c1

InChI Key InChIKey=PUXBKFXYQQCQAS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652625   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652625BDBM652625(US20240059691, Example 2205 | 6-N-({2-fluoro-4-[({...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent