BDBM652703 5-N-[(2-{[(1R,5S)-3-methyl-3-azabicyclo[3.1.0]hexan-6-yl]methoxy}pyridin-4- yl)methyl]isoquinoline-1,5-diamine::US20240059691, Example 4418

SMILES CN1C[C@H]2C(COc3cc(CNc4cccc5c(N)nccc45)ccn3)[C@H]2C1

InChI Key InChIKey=KKMDOLSFQQCZGC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652703   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652703BDBM652703(US20240059691, Example 4418 | 5-N-[(2-{[(1R,5S)-3-...)
Affinity DataIC50: 650nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent