BDBM652709 N5-((2-((1,4-dimethylpiperidin-4-yl)methoxy)pyridin-4-yl)methyl)isoquinoline-1,5- diamine::US20240059691, Example 4424

SMILES CN1CCC(C)(COc2cc(CNc3cccc4c(N)nccc34)ccn2)CC1

InChI Key InChIKey=DHKUTIQQPVLBKH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 652709   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652709BDBM652709(US20240059691, Example 4424 | N5-((2-((1,4-dimethy...)
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent