BDBM652748 N5-((2-((5-cyclopropyl-4-methyl-4H-1,2,4-triazol-3-yl)methoxy)pyridin-4- yl)methyl)isoquinoline-1,5-diamine::US20240059691, Example 4468

SMILES Cn1c(COc2cc(CNc3cccc4c(N)nccc34)ccn2)nnc1C1CC1

InChI Key InChIKey=VCSMMVIIOANDQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 652748   

TargetCoagulation factor XII(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652748BDBM652748(US20240059691, Example 4468 | N5-((2-((5-cycloprop...)
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of Factor XIIa was determined using an IC50 assay based on standard literature methods (see e.g Baeriswyl et al., ACS Chem. Biol....More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 652748BDBM652748(US20240059691, Example 4468 | N5-((2-((5-cycloprop...)
Affinity DataIC50: 7.00E+4nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent